Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.1
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.6
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Folate[5,000 mcg (6S)-5-MTHF**][from Quatrefolic® (6S)-5-MTHF**Glucosamine Salt]
8,333 mcg DFE
2083%
Top Medical Research Studies
8
We explored a unique case of recurrent fainting after hysteroscopy, ultimately revealed as cerebral venous sinus thrombosis (CVST). This rare condition can mimic symptoms of more common complications like TURP syndrome, making diagnosis tricky.
Our patient, a 33-year-old woman, experienced multiple episodes of syncope and nausea shortly after her surgery. Administration of anticoagulants and folic acid, among other treatments, led to recovery. This case highlights the need for awareness of underlying vascular issues when typical surgery complications are ruled out.
Our patient, a 33-year-old woman, experienced multiple episodes of syncope and nausea shortly after her surgery. Administration of anticoagulants and folic acid, among other treatments, led to recovery. This case highlights the need for awareness of underlying vascular issues when typical surgery complications are ruled out.
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8
We examined the case of a healthy 12-year-old girl who experienced a central retinal vein occlusion. This incident was particularly notable because she later developed retinal neovascularization at the age of 24. This timing marks the longest gap reported between such a pediatric event and subsequent complications.
Throughout the evaluation, we noted that the girl's family history was not significant for similar conditions. However, laboratory tests flagged a mildly elevated homocysteine level and uncovered a homozygous C677T mutation in methylenetetrahydrofolate reductase. As a proactive measure, we initiated folate supplementation to possibly mitigate future thrombotic risks.
So far, this approach has shown promise, as the patient has not experienced further ocular or systemic clotting issues. Our findings suggest that folate supplementation may play a beneficial role in managing elevated homocysteine levels, which are associated with blood clotting complications.
This case highlights the importance of a thorough systemic workup and the necessity for long-term follow-up in pediatric patients with central retinal vein occlusion. By taking measures like folate supplementation, we aim to prevent serious complications such as intraocular hemorrhage and neovascular glaucoma.
Throughout the evaluation, we noted that the girl's family history was not significant for similar conditions. However, laboratory tests flagged a mildly elevated homocysteine level and uncovered a homozygous C677T mutation in methylenetetrahydrofolate reductase. As a proactive measure, we initiated folate supplementation to possibly mitigate future thrombotic risks.
So far, this approach has shown promise, as the patient has not experienced further ocular or systemic clotting issues. Our findings suggest that folate supplementation may play a beneficial role in managing elevated homocysteine levels, which are associated with blood clotting complications.
This case highlights the importance of a thorough systemic workup and the necessity for long-term follow-up in pediatric patients with central retinal vein occlusion. By taking measures like folate supplementation, we aim to prevent serious complications such as intraocular hemorrhage and neovascular glaucoma.
Read More
7
We investigated how folic acid supplementation affects blood clots in patients with end-stage kidney disease (ESKD) undergoing hemodialysis. Our research used patient data from the Chang Gung Medical Foundation and compared daily versus weekly folic acid dosages.
Interestingly, patients taking daily folic acid showed a lower rate of arteriovenous access thrombosis compared to those on weekly supplements. However, both groups had similar rates of other serious cardiovascular events, suggesting that while daily supplementation may help with thrombosis, it does not significantly impact overall cardiovascular health.
Interestingly, patients taking daily folic acid showed a lower rate of arteriovenous access thrombosis compared to those on weekly supplements. However, both groups had similar rates of other serious cardiovascular events, suggesting that while daily supplementation may help with thrombosis, it does not significantly impact overall cardiovascular health.
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Most Useful Reviews
7.5
Cardiovascular benefits
1 people found this helpful
Reduces the risk of cardiovascular diseases, strokes, and blood clots by lowering homocysteine levels. It maintains normal renewal rates while ensuring excellent quality.
Read More
0
Avoid overdose warning
4 people found this helpful
BEWARE OF DOSAGE!! I began taking this supplement a month ago and followed the bottle's instruction of 1 capsule daily, which contains 5000 mcg—five times the recommended maximum of 1000 mcg/day! I experienced severe bloating and poor liver values. They should not sell this!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.1
- All Researches
9
Supplementation improves health outcomes
We conducted a multi-center trial in Romania to explore how vitamin B12, folic acid, and vitamin D3 supplements could help lower homocysteine levels in Parkinson's disease patients on levodopa treatment.
Over six months, we observed that participants who took these supplements experienced a significant reduction in homocysteine levels and an improvement in their overall quality of life.
The findings suggest that nutritional support can play a vital role in managing Parkinson's disease, potentially reducing risks associated with elevated homocysteine, such as blood clots and other complications.
Over six months, we observed that participants who took these supplements experienced a significant reduction in homocysteine levels and an improvement in their overall quality of life.
The findings suggest that nutritional support can play a vital role in managing Parkinson's disease, potentially reducing risks associated with elevated homocysteine, such as blood clots and other complications.
Read More
8
We explored a unique case of recurrent fainting after hysteroscopy, ultimately revealed as cerebral venous sinus thrombosis (CVST). This rare condition can mimic symptoms of more common complications like TURP syndrome, making diagnosis tricky.
Our patient, a 33-year-old woman, experienced multiple episodes of syncope and nausea shortly after her surgery. Administration of anticoagulants and folic acid, among other treatments, led to recovery. This case highlights the need for awareness of underlying vascular issues when typical surgery complications are ruled out.
Our patient, a 33-year-old woman, experienced multiple episodes of syncope and nausea shortly after her surgery. Administration of anticoagulants and folic acid, among other treatments, led to recovery. This case highlights the need for awareness of underlying vascular issues when typical surgery complications are ruled out.
Read More
8
We examined a unique case of cerebral venous thrombosis in a 14-year-old girl, associated with hyperhomocysteinemia and a rare mutation at the MTHFR locus. The patient displayed symptoms like headaches and nausea, with significantly elevated homocysteine levels.
After receiving a combination of anticoagulation therapy and supplementation with folate, B12, and B6, her condition improved remarkably over a month, reducing intracranial pressure and alleviating symptoms. This case emphasizes the importance of such genetic analysis in similar thrombotic cases.
After receiving a combination of anticoagulation therapy and supplementation with folate, B12, and B6, her condition improved remarkably over a month, reducing intracranial pressure and alleviating symptoms. This case emphasizes the importance of such genetic analysis in similar thrombotic cases.
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8
We explored how folic acid (FA) affects blood clotting in a study that examined the impact of carbon black (CB) on mice. Over 28 days, mice exposed to CB showed increased blood clotting due to changes in spleen activity and elevated platelet counts.
Interestingly, lower levels of folic acid were noted after CB exposure. However, administering folic acid helped restore normal blood coagulation levels by inhibiting certain inflammatory pathways. Despite these findings, it’s important to state that this study primarily exposes potential mechanisms rather than confirming definitive benefits of folic acid for humans.
Interestingly, lower levels of folic acid were noted after CB exposure. However, administering folic acid helped restore normal blood coagulation levels by inhibiting certain inflammatory pathways. Despite these findings, it’s important to state that this study primarily exposes potential mechanisms rather than confirming definitive benefits of folic acid for humans.
Read More
8
We examined the case of a healthy 12-year-old girl who experienced a central retinal vein occlusion. This incident was particularly notable because she later developed retinal neovascularization at the age of 24. This timing marks the longest gap reported between such a pediatric event and subsequent complications.
Throughout the evaluation, we noted that the girl's family history was not significant for similar conditions. However, laboratory tests flagged a mildly elevated homocysteine level and uncovered a homozygous C677T mutation in methylenetetrahydrofolate reductase. As a proactive measure, we initiated folate supplementation to possibly mitigate future thrombotic risks.
So far, this approach has shown promise, as the patient has not experienced further ocular or systemic clotting issues. Our findings suggest that folate supplementation may play a beneficial role in managing elevated homocysteine levels, which are associated with blood clotting complications.
This case highlights the importance of a thorough systemic workup and the necessity for long-term follow-up in pediatric patients with central retinal vein occlusion. By taking measures like folate supplementation, we aim to prevent serious complications such as intraocular hemorrhage and neovascular glaucoma.
Throughout the evaluation, we noted that the girl's family history was not significant for similar conditions. However, laboratory tests flagged a mildly elevated homocysteine level and uncovered a homozygous C677T mutation in methylenetetrahydrofolate reductase. As a proactive measure, we initiated folate supplementation to possibly mitigate future thrombotic risks.
So far, this approach has shown promise, as the patient has not experienced further ocular or systemic clotting issues. Our findings suggest that folate supplementation may play a beneficial role in managing elevated homocysteine levels, which are associated with blood clotting complications.
This case highlights the importance of a thorough systemic workup and the necessity for long-term follow-up in pediatric patients with central retinal vein occlusion. By taking measures like folate supplementation, we aim to prevent serious complications such as intraocular hemorrhage and neovascular glaucoma.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.6
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Cardiovascular benefits
1 people found this helpful
Reduces the risk of cardiovascular diseases, strokes, and blood clots by lowering homocysteine levels. It maintains normal renewal rates while ensuring excellent quality.
Read More
0
Avoid overdose warning
4 people found this helpful
BEWARE OF DOSAGE!! I began taking this supplement a month ago and followed the bottle's instruction of 1 capsule daily, which contains 5000 mcg—five times the recommended maximum of 1000 mcg/day! I experienced severe bloating and poor liver values. They should not sell this!
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Zhang Y, Ye H, Chen D, Yan G, Li Z, et al. Recurrent syncope after hysteroscopy finally diagnosed as cerebral venous sinus thrombosis: a case report. AJOG Glob Rep. 2025;5:100446. 10.1016/j.xagr.2025.100446
- Turcu-Stiolica A, Naidin MS, Halmagean S, Ionescu AM, Pirici I. The Impact of the Dietary Intake of Vitamin B12, Folic Acid, and Vitamin D3 on Homocysteine Levels and the Health-Related Quality of Life of Levodopa-Treated Patients with Parkinson's Disease-A Pilot Study in Romania. Diagnostics (Basel). 2024;14. 10.3390/diagnostics14151609
- Zhang M, Shi B, Zhao M. Cerebral venous thrombosis with hyperhomocysteinemia due to loss of heterozygosity at methylenetetrahydrofolate reductase (MTHFR) locus: a case report. BMC Neurol. 2023;23:154. 10.1186/s12883-023-03200-y
- Lin SS, Fan IW, Chen CY, Su YJ. A nitrous oxide abuser presenting with cerebral venous thrombosis: A case report. Med Int (Lond). 2022;2:20. 10.3892/mi.2022.45
- Tu YR, Tu KH, Lee CC, Fan PC, Yen CL, et al. Supplementation with Folic Acid and Cardiovascular Outcomes in End-Stage Kidney Disease: A Multi-Institution Cohort Study. Nutrients. 2022;14. 10.3390/nu14194162
- Chaloulis SK, Tsaousis KT. Cystoid Macular Edema Associated With Venous Stasis in a Patient With Previously Undiagnosed Hyperhomocysteinemia. Cureus. 2021;13:e20782. 10.7759/cureus.20782
- Lauretta MP, Melotti RM, Sangermano C, George AM, Badenes R, et al. Homocysteine Plasmatic Concentration in Brain-Injured Neurocritical Care Patients: Systematic Review of Clinical Evidence. J Clin Med. 2022;11. 10.3390/jcm11020394
- Meng Q, Li B, Huang N, Wei S, Ren Q, et al. Folic acid targets splenic extramedullary hemopoiesis to attenuate carbon black-induced coagulation-thrombosis potential. J Hazard Mater. 2022;424:127354. 10.1016/j.jhazmat.2021.127354
- Cao Y, Yao T, Chen H, Liu H, Li C, et al. The association of serum folate and homocysteine on venous thromboembolism in patients with colorectal cancer: a cross-sectional study. Transl Cancer Res. 2023;12:125. 10.21037/tcr-22-2839
- Sikora M, Skrzydlewski P, Perła-Kaján J, Jakubowski H. Homocysteine thiolactone contributes to the prognostic value of fibrin clot structure/function in coronary artery disease. PLoS One. 2022;17:e0275956. 10.1371/journal.pone.0275956
- Hudson JL, Laura DM, Berrocal AM. CENTRAL RETINAL VEIN OCCLUSION IN 12-YEAR-OLD GIRL WITH METHYLENETETRAHYDROFOLATE REDUCTASE MUTATION: A CASE REPORT AND REVIEW OF THE LITERATURE. Retin Cases Brief Rep. 2023;17:734. 10.1097/ICB.0000000000001283
